Fans who were expecting a fifth season of the "Masters of Sex" drama series will be disappointed to know that Showtime has decided to completely cancel the show. The fourth and final season of the series aired its finale on November 10 with William Masters (played by Michael Sheen) and Virgina Johnson (played by Lizzy Caplan) finally exchanging their "I do's" to one another.

News of the series cancellation was first reported by Deadline, and the website posted a statement from Showtime confirming that it will not be renewing the "Masters of Sex" for the fifth season. In its statement, Showtime called the show a "beautifully written and acted exploration of America's changing sexual mores." They ended their statement stating how proud they are of the critically acclaimed show, which ran for four seasons and that the series would be made available on all of their platforms so that new viewers can access it.

"Master of Sex" premiered in 2013 and was loosely based on the Thomas Miller's autobiography of William Masters and Virginia Johnson, who would later be known as pioneers in the research of human sexuality. "Masters of Sex" is set in the 1950s then, progressed to the 1960s during its second and third seasons, before finally ending during the swinging 70's in its fourth and final season.

"Masters of Sex" was a hit among critics and would go on to earn ten Emmy nominations during its four season run. Allison Janney's portrayal of Margaret Scully, who is the sexually frustrated wife of Masters' longtime friend Barton (played by Beau Bridges) that earned her an Emmy Award for Outstanding Guest Actress in a Drama Series.

Despite receiving universal praise from critics, the show was only able to bring in modest ratings for Showtime and the final episode attracted only a mere 457,000 viewers. According to the Hollywood Reporter, season 4 was averaging less than 800,000 viewers, which is apparently not enough for the show to continue. The scientific analysis of human's sexual exploration will surely be missed by its avid viewers.